KEGG   NETWORK: N00128Help
Entry
N00128                      Network                                

Name
TMPRSS2-ERG fusion to transcriptional activation
Definition
TMPRSS2-ERG => (PLAU,PLAT,MMP3,MMP9,ZEB1,IL1R2)
  Expanded
2078v1 => (5328,5327,4314,4318,6935,7850)
Class
nt06240 Transcription
nt06272 Prostate cancer
Type
Variant
Pathway
hsa05202  Transcriptional misregulation in cancer
Disease
H00024  Prostate cancer
Gene
2078  ERG; ERG, ETS transcription factor
5328  PLAU; plasminogen activator, urokinase
5327  PLAT; plasminogen activator, tissue type
4314  MMP3; matrix metallopeptidase 3
4318  MMP9; matrix metallopeptidase 9
6935  ZEB1; zinc finger E-box binding homeobox 1
7850  IL1R2; interleukin 1 receptor type 2
Variant
2078v1  TMPRSS2-ERG fusion
Reference
  Authors
Leshem O, Madar S, Kogan-Sakin I, Kamer I, Goldstein I, Brosh R, Cohen Y, Jacob-Hirsch J, Ehrlich M, Ben-Sasson S, Goldfinger N, Loewenthal R, Gazit E, Rotter V, Berger R
  Title
TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
  Journal
PLoS One 6:e21650 (2011)
DOI:10.1371/journal.pone.0021650
Reference
  Authors
Yu J, Yu J, Mani RS, Cao Q, Brenner CJ, Cao X, Wang X, Wu L, Li J, Hu M, Gong Y, Cheng H, Laxman B, Vellaichamy A, Shankar S, Li Y, Dhanasekaran SM, Morey R, Barrette T, Lonigro RJ, Tomlins SA, Varambally S, Qin ZS, Chinnaiyan AM
  Title
An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
  Journal
Cancer Cell 17:443-54 (2010)
DOI:10.1016/j.ccr.2010.03.018
Reference
  Authors
Squire JA
  Title
TMPRSS2-ERG and PTEN loss in prostate cancer.
  Journal
Nat Genet 41:509-10 (2009)
DOI:10.1038/ng0509-509
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