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Entry
N00129                      Network                                

Name
TMPRSS2-ERG fusion to transcriptional repression
Definition
TMPRSS2-ERG =| SPINT1
  Expanded
2078v1 =| 6692
Class
nt06240 Transcription
nt06272 Prostate cancer
Type
Variant
Pathway
hsa05202  Transcriptional misregulation in cancer
Disease
H00024  Prostate cancer
Gene
2078  ERG; ERG, ETS transcription factor
6692  SPINT1; serine peptidase inhibitor, Kunitz type 1
Variant
2078v1  TMPRSS2-ERG fusion
Reference
  Authors
Leshem O, Madar S, Kogan-Sakin I, Kamer I, Goldstein I, Brosh R, Cohen Y, Jacob-Hirsch J, Ehrlich M, Ben-Sasson S, Goldfinger N, Loewenthal R, Gazit E, Rotter V, Berger R
  Title
TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
  Journal
PLoS One 6:e21650 (2011)
DOI:10.1371/journal.pone.0021650
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