KEGG   NETWORK: N00130Help
Entry
N00130                      Network                                

Name
TMPRSS2-ETV5 fusion to transcriptional activation
Definition
TMPRSS2-ETV5 => (PLAU,MMP9)
  Expanded
2119v1 => (5328,4318)
Class
nt06240 Transcription
nt06272 Prostate cancer
Type
Variant
Pathway
hsa05202  Transcriptional misregulation in cancer
Disease
H00024  Prostate cancer
Gene
2119  ETV5; ETS variant 5
5328  PLAU; plasminogen activator, urokinase
4318  MMP9; matrix metallopeptidase 9
Variant
2119v1  TMPRSS2-ETV5 fusion
Reference
  Authors
Helgeson BE, Tomlins SA, Shah N, Laxman B, Cao Q, Prensner JR, Cao X, Singla N, Montie JE, Varambally S, Mehra R, Chinnaiyan AM
  Title
Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
  Journal
Cancer Res 68:73-80 (2008)
DOI:10.1158/0008-5472.CAN-07-5352
Reference
  Authors
Kim H, Datta A, Talwar S, Saleem SN, Mondal D, Abdel-Mageed AB
  Title
Estradiol-ERbeta2 signaling axis confers growth and migration of CRPC cells through TMPRSS2-ETV5 gene fusion.
  Journal
Oncotarget 8:62820-62833 (2017)
DOI:10.18632/oncotarget.11355
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