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Entry
N00131                      Network                                

Name
Amplified MYCN to transcriptional activation
Definition
MYCN* -- MAX => (MDM2,PTK2,TP53,BMI1)
  Expanded
4613v1 -- 4149 => (4193,5747,7157,648)
Class
nt06240 Transcription
Type
Variant
Pathway
hsa05202  Transcriptional misregulation in cancer
Disease
H00043  Neuroblastoma
Gene
4613  MYCN; MYCN proto-oncogene, bHLH transcription factor
4149  MAX; MYC associated factor X
4193  MDM2; MDM2 proto-oncogene
5747  PTK2; protein tyrosine kinase 2
7157  TP53; tumor protein p53
648  BMI1; BMI1 proto-oncogene, polycomb ring finger
Variant
4613v1  MYCN amplification
Reference
  Authors
Westermark UK, Wilhelm M, Frenzel A, Henriksson MA
  Title
The MYCN oncogene and differentiation in neuroblastoma.
  Journal
Semin Cancer Biol 21:256-66 (2011)
DOI:10.1016/j.semcancer.2011.08.001
Reference
  Authors
Bell E, Chen L, Liu T, Marshall GM, Lunec J, Tweddle DA
  Title
MYCN oncoprotein targets and their therapeutic potential.
  Journal
Cancer Lett 293:144-57 (2010)
DOI:10.1016/j.canlet.2010.01.015
Reference
  Authors
Slack A, Chen Z, Tonelli R, Pule M, Hunt L, Pession A, Shohet JM
  Title
The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
  Journal
Proc Natl Acad Sci U S A 102:731-6 (2005)
DOI:10.1073/pnas.0405495102
Reference
  Authors
Beierle EA, Trujillo A, Nagaram A, Kurenova EV, Finch R, Ma X, Vella J, Cance WG, Golubovskaya VM
  Title
N-MYC regulates focal adhesion kinase expression in human neuroblastoma.
  Journal
J Biol Chem 282:12503-16 (2007)
DOI:10.1074/jbc.M701450200
Reference
  Authors
Chen L, Iraci N, Gherardi S, Gamble LD, Wood KM, Perini G, Lunec J, Tweddle DA
  Title
p53 is a direct transcriptional target of MYCN in neuroblastoma.
  Journal
Cancer Res 70:1377-88 (2010)
DOI:10.1158/0008-5472.CAN-09-2598
Reference
  Authors
Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T
  Title
Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
  Journal
Oncogene 29:2681-90 (2010)
DOI:10.1038/onc.2010.22
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