KEGG   NETWORK: N00132
Entry
N00132                      Network                                

Name
Amplified MYCN to transcriptional repression
Definition
MYCN* -- MAX -- (SP1+ZBTB17) => (NTRK1,NGFR)
  Expanded
4613v1 -- 4149 -- (6667+7709) => (4914,4804)
Class
nt06240 Transcription
Type
Variant
Disease
H00043  Neuroblastoma
Gene
4613  MYCN; MYCN proto-oncogene, bHLH transcription factor
4149  MAX; MYC associated factor X
6667  SP1; Sp1 transcription factor
7709  ZBTB17; zinc finger and BTB domain containing 17
4914  NTRK1; neurotrophic receptor tyrosine kinase 1
4804  NGFR; nerve growth factor receptor
Variant
4613v1 (MYCN*)  MYCN amplification
Reference
  Authors
Westermark UK, Wilhelm M, Frenzel A, Henriksson MA
  Title
The MYCN oncogene and differentiation in neuroblastoma.
  Journal
Semin Cancer Biol 21:256-66 (2011)
DOI:10.1016/j.semcancer.2011.08.001
Reference
  Authors
Iraci N, Diolaiti D, Papa A, Porro A, Valli E, Gherardi S, Herold S, Eilers M, Bernardoni R, Della Valle G, Perini G
  Title
A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.
  Journal
Cancer Res 71:404-12 (2011)
DOI:10.1158/0008-5472.CAN-10-2627
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