KEGG   NETWORK: N00132Help
Entry
N00132                      Network                                

Name
Amplified MYCN to transcriptional repression
Definition
MYCN* -- MAX -- (SP1+ZBTB17) => (NTRK1,NGFR)
  Expanded
4613v1 -- 4149 -- (6667+7709) => (4914,4804)
Class
nt06240 Transcription
Type
Variant
Pathway
hsa05202  Transcriptional misregulation in cancer
Disease
H00043  Neuroblastoma
Gene
4613  MYCN; MYCN proto-oncogene, bHLH transcription factor
4149  MAX; MYC associated factor X
6667  SP1; Sp1 transcription factor
7709  ZBTB17; zinc finger and BTB domain containing 17
4914  NTRK1; neurotrophic receptor tyrosine kinase 1
4804  NGFR; nerve growth factor receptor
Variant
4613v1  MYCN amplification
Reference
  Authors
Westermark UK, Wilhelm M, Frenzel A, Henriksson MA
  Title
The MYCN oncogene and differentiation in neuroblastoma.
  Journal
Semin Cancer Biol 21:256-66 (2011)
DOI:10.1016/j.semcancer.2011.08.001
Reference
  Authors
Iraci N, Diolaiti D, Papa A, Porro A, Valli E, Gherardi S, Herold S, Eilers M, Bernardoni R, Della Valle G, Perini G
  Title
A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.
  Journal
Cancer Res 71:404-12 (2011)
DOI:10.1158/0008-5472.CAN-10-2627
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