KEGG   NETWORK: N00133Help
Entry
N00133                      Network                                

Name
EWSR1-FLI1 fusion to transcriptional activation
Definition
EWSR1-FLI1 => (IGF1,MYC,ID2)
  Expanded
2313v1 => (3479,4609,3398)
Class
nt06240 Transcription
Type
Variant
Pathway
hsa05202  Transcriptional misregulation in cancer
Disease
H00035  Ewing sarcoma
Gene
2313  FLI1; Fli-1 proto-oncogene, ETS transcription factor
3479  IGF1; insulin like growth factor 1
4609  MYC; MYC proto-oncogene, bHLH transcription factor
3398  ID2; inhibitor of DNA binding 2, HLH protein
Variant
2313v1  EWSR1-FLI1 fusion
Reference
  Authors
Ordonez JL, Osuna D, Herrero D, de Alava E, Madoz-Gurpide J
  Title
Advances in Ewing's sarcoma research: where are we now and what lies ahead?
  Journal
Cancer Res 69:7140-50 (2009)
DOI:10.1158/0008-5472.CAN-08-4041
Reference
  Authors
Riggi N, Stamenkovic I.
  Title
The Biology of Ewing sarcoma.
  Journal
Cancer Lett 254:1-10 (2007)
DOI:10.1016/j.canlet.2006.12.009
Reference
  Authors
Jedlicka P
  Title
Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.
  Journal
Int J Clin Exp Pathol 3:338-47 (2010)
Reference
  Authors
Cironi L, Riggi N, Provero P, Wolf N, Suva ML, Suva D, Kindler V, Stamenkovic I
  Title
IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.
  Journal
PLoS One 3:e2634 (2008)
DOI:10.1371/journal.pone.0002634
Reference
  Authors
Fukuma M, Okita H, Hata J, Umezawa A
  Title
Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.
  Journal
Oncogene 22:1-9 (2003)
DOI:10.1038/sj.onc.1206055
Reference
  Authors
Aman P
  Title
Fusion oncogenes in tumor development.
  Journal
Semin Cancer Biol 15:236-43 (2005)
DOI:10.1016/j.semcancer.2005.01.009
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