KEGG   NETWORK: N00135Help
Entry
N00135                      Network                                

Name
EWSR1-ERG fusion to transcriptional activation
Definition
EWSR1-ERG => IGF1
  Expanded
2078v2 => 3479
Class
nt06240 Transcription
Type
Variant
Pathway
hsa05202  Transcriptional misregulation in cancer
Disease
H00035  Ewing sarcoma
Gene
2078  ERG; ERG, ETS transcription factor
3479  IGF1; insulin like growth factor 1
Variant
2078v2  EWSR1-ERG fusion
Reference
  Authors
Cironi L, Riggi N, Provero P, Wolf N, Suva ML, Suva D, Kindler V, Stamenkovic I
  Title
IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.
  Journal
PLoS One 3:e2634 (2008)
DOI:10.1371/journal.pone.0002634
Reference
  Authors
Aman P
  Title
Fusion oncogenes in tumor development.
  Journal
Semin Cancer Biol 15:236-43 (2005)
DOI:10.1016/j.semcancer.2005.01.009
Reference
  Authors
Helman LJ, Meltzer P.
  Title
Mechanisms of sarcoma development.
  Journal
Nat Rev Cancer 3:685-94 (2003)
DOI:10.1038/nrc1168
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