KEGG   NETWORK: N00140Help
Entry
N00140                      Network                                

Name
FUS-DDIT3 fusion to NFKB-mediated transcription
Definition
FUS-DDIT3 -- (NFKBIZ+NFKB) => CXCL8
  Expanded
1649v1 -- (64332+4790+5970) => 3576
Class
nt06240 Transcription
Type
Variant
Pathway
hsa05202  Transcriptional misregulation in cancer
Disease
H00049  Myxoid liposarcoma
Gene
1649  DDIT3; DNA damage inducible transcript 3
64332  NFKBIZ; NFKB inhibitor zeta
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
3576  CXCL8; C-X-C motif chemokine ligand 8
Variant
1649v1  FUS-DDIT3 fusion
Reference
  Authors
Goransson M, Andersson MK, Forni C, Stahlberg A, Andersson C, Olofsson A, Mantovani R, Aman P
  Title
The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.
  Journal
Oncogene 28:270-8 (2009)
DOI:10.1038/onc.2008.378
Reference
  Authors
Willems SM, Schrage YM, Bruijn IH, Szuhai K, Hogendoorn PC, Bovee JV
  Title
Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
  Journal
Mol Cancer 9:257 (2010)
DOI:10.1186/1476-4598-9-257
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