KEGG   NETWORK: N00144Help
Entry
N00144                      Network                                

Name
TLX1 rearrangement to transcriptional repression
Definition
TLX1* =| BCL11B
  Expanded
3195v1 =| 64919
Class
nt06240 Transcription
Type
Variant
Pathway
hsa05202  Transcriptional misregulation in cancer
Disease
H00002  T-cell acute lymphoblastic leukemia
Gene
3195  TLX1; T-cell leukemia homeobox 1
64919  BCL11B; B-cell CLL/lymphoma 11B
Variant
3195v1  TLX1 rearrangemnet
Reference
  Authors
De Keersmaecker K, Ferrando AA
  Title
TLX1-induced T-cell acute lymphoblastic leukemia.
  Journal
Clin Cancer Res 17:6381-6 (2011)
DOI:10.1158/1078-0432.CCR-10-3037
Reference
  Authors
Hoang T, Hoang T
  Title
The T-ALL paradox in cancer.
  Journal
Nat Med 16:1185-6 (2010)
DOI:10.1038/nm1110-1185
Reference
  Authors
De Keersmaecker K, Real PJ, Gatta GD, Palomero T, Sulis ML, Tosello V, Van Vlierberghe P, Barnes K, Castillo M, Sole X, Hadler M, Lenz J, Aplan PD, Kelliher M, Kee BL, Pandolfi PP, Kappes D, Gounari F, Petrie H, Van der Meulen J, Speleman F, Paietta E, Racevskis J, Wiernik PH, Rowe JM, Soulier J, Avran D, Cave H, Dastugue N, Raimondi S, Meijerink JP, Cordon-Cardo C, Califano A, Ferrando AA
  Title
The TLX1 oncogene drives aneuploidy in T cell transformation.
  Journal
Nat Med 16:1321-7 (2010)
DOI:10.1038/nm.2246
Reference
  Authors
Ha VL, Luong A, Li F, Casero D, Malvar J, Kim YM, Bhatia R, Crooks GM, Parekh C
  Title
The T-ALL related gene BCL11B regulates the initial stages of human T-cell differentiation.
  Journal
Leukemia 31:2503-2514 (2017)
DOI:10.1038/leu.2017.70
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