KEGG   NETWORK: N00146
Entry
N00146                      Network                                

Name
Crosstalk between extrinsic and intrinsic apoptotic pathways
Definition
FASLG -> FAS -> FADD -> CASP8 -> BID -> (BAX,BAK1) -> CYCS -- APAF1 -> CASP9 -> (CASP3,CASP7)
  Expanded
356 -> 355 -> 8772 -> 841 -> 637 -> (581,578) -> 54205 -- 317 -> 842 -> (836,840)
Class
nt06231 Apoptosis
nt06263 Hepatocellular carcinoma
nt06414 Apoptosis
nt06460 Alzheimer disease
nt06131 Apoptosis (viruses and bacteria)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
nt06162 Hepatitis B virus (HBV)
nt06163 Hepatitis C virus (HCV)
nt06168 Herpes simplex virus 1 (HSV-1)
nt06167 Human cytomegalovirus (HCMV)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165 Epstein-Barr virus (EBV)
Type
Reference
Pathway
hsa04210  Apoptosis
Gene
356  FASLG; Fas ligand
355  FAS; Fas cell surface death receptor
8772  FADD; Fas associated via death domain
841  CASP8; caspase 8
637  BID; BH3 interacting domain death agonist
581  BAX; BCL2 associated X, apoptosis regulator
578  BAK1; BCL2 antagonist/killer 1
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
840  CASP7; caspase 7
Reference
  Authors
Vucic D, Dixit VM, Wertz IE
  Title
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death.
  Journal
Nat Rev Mol Cell Biol 12:439-52 (2011)
DOI:10.1038/nrm3143
Reference
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
  Authors
Tait SW, Green DR
  Title
Mitochondria and cell death: outer membrane permeabilization and beyond.
  Journal
Nat Rev Mol Cell Biol 11:621-32 (2010)
DOI:10.1038/nrm2952
Reference
  Authors
Beesoo R, Neergheen-Bhujun V, Bhagooli R, Bahorun T
  Title
Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment.
  Journal
Mutat Res 768:84-97 (2014)
DOI:10.1016/j.mrfmmm.2014.03.005
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