| Entry |
|
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| Name |
Crosstalk between extrinsic and intrinsic apoptotic pathways
|
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| Definition |
FASLG -> FAS -> FADD -> CASP8 -> BID -> (BAX,BAK1) -> CYCS -- APAF1 -> CASP9 -> (CASP3,CASP7) |
|---|
| Expanded |
356 -> 355 -> 8772 -> 841 -> 637 -> (581,578) -> 54205 -- 317 -> 842 -> (836,840) |
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| Class |
nt06231 Apoptosis
nt06263 Hepatocellular carcinoma
nt06131 Apoptosis (viruses and bacteria)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
nt06162 Hepatitis B virus (HBV)
nt06163 Hepatitis C virus (HCV)
nt06168 Herpes simplex virus 1 (HSV-1)
nt06167 Human cytomegalovirus (HCMV)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165 Epstein-Barr virus (EBV)
|
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| Type |
Reference
|
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| Pathway |
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| Gene |
| 355 | FAS; Fas cell surface death receptor |
| 8772 | FADD; Fas associated via death domain |
| 637 | BID; BH3 interacting domain death agonist |
| 581 | BAX; BCL2 associated X, apoptosis regulator |
| 578 | BAK1; BCL2 antagonist/killer 1 |
| 54205 | CYCS; cytochrome c, somatic |
| 317 | APAF1; apoptotic peptidase activating factor 1 |
|
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| Reference |
|
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| Authors |
Vucic D, Dixit VM, Wertz IE |
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| Title |
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death. |
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| Journal |
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| Reference |
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| Authors |
Strasser A |
|---|
| Title |
The role of BH3-only proteins in the immune system. |
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| Journal |
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| Reference |
|
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| Authors |
Tait SW, Green DR |
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| Title |
Mitochondria and cell death: outer membrane permeabilization and beyond. |
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| Journal |
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| Reference |
|
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| Authors |
Beesoo R, Neergheen-Bhujun V, Bhagooli R, Bahorun T |
|---|
| Title |
Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment. |
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| Journal |
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| LinkDB |
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