KEGG   NETWORK: N00147Help
Entry
N00147                      Network                                

Name
EGF-EGFR-PLCG-calcineurin signaling pathway
Definition
EGF -> EGFR -> PLCG -> IP3 -> Ca2+ -> CALM -- CN -> NFAT
  Expanded
1950 -> 1956 -> (5335,5336) -> C01245 -> C00076 -> (801,805,808) -- (5530,5532,5533,5534,5535) -> (4772,4773,4775,4776)
Class
nt06220 Calcium signaling
nt06120 Calcium signaling (virus)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
hsa04020  Calcium signaling pathway
Gene
1950  EGF; epidermal growth factor
1956  EGFR; epidermal growth factor receptor
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
801  CALM1; calmodulin 1
805  CALM2; calmodulin 2
808  CALM3; calmodulin 3
5530  PPP3CA; protein phosphatase 3 catalytic subunit alpha
5532  PPP3CB; protein phosphatase 3 catalytic subunit beta
5533  PPP3CC; protein phosphatase 3 catalytic subunit gamma
5534  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha
5535  PPP3R2; protein phosphatase 3 regulatory subunit B, beta
4772  NFATC1; nuclear factor of activated T-cells 1
4773  NFATC2; nuclear factor of activated T-cells 2
4775  NFATC3; nuclear factor of activated T-cells 3
4776  NFATC4; nuclear factor of activated T-cells 4
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
Reference
  Authors
Roderick HL, Cook SJ
  Title
Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival.
  Journal
Nat Rev Cancer 8:361-75 (2008)
DOI:10.1038/nrc2374
Reference
  Authors
Slusarski DC, Pelegri F
  Title
Calcium signaling in vertebrate embryonic patterning and morphogenesis.
  Journal
Dev Biol 307:1-13 (2007)
DOI:10.1016/j.ydbio.2007.04.043
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