KEGG   NETWORK: N00148Help
Entry
N00148                      Network                                

Name
TLR3-IRF7 signaling pathway
Definition
TLR3 -> TICAM1 -> TRAF3 -> (IKBKE+TBK1) -> IRF7 => IFNA
  Expanded
7098 -> 148022 -> 7187 -> (9641+29110) -> 3665 => (3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452)
Class
nt06221 TLR signaling
nt06121 TLR signaling (viruses and bacteria)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
hsa04620 Toll-like receptor signaling pathway   
Gene
7098  TLR3; toll like receptor 3
148022  TICAM1; toll like receptor adaptor molecule 1
7187  TRAF3; TNF receptor associated factor 3
9641  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon
29110  TBK1; TANK binding kinase 1
3665  IRF7; interferon regulatory factor 7
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
Reference
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and Type I interferons.
  Journal
J Biol Chem 282:15319-23 (2007)
DOI:10.1074/jbc.R700009200
Reference
  Authors
Akira S, Uematsu S, Takeuchi O.
  Title
Pathogen recognition and innate immunity.
  Journal
Cell 124:783-801 (2006)
DOI:10.1016/j.cell.2006.02.015
Reference
  Authors
Boo KH, Yang JS
  Title
Intrinsic cellular defenses against virus infection by antiviral type I interferon.
  Journal
Yonsei Med J 51:9-17 (2010)
DOI:10.3349/ymj.2010.51.1.9
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