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Entry
N00150                      Network                                

Name
Type I IFN signaling pathway
Definition
(IFNA,IFNB1) -> (IFNAR1+IFNAR2) -> (JAK1,TYK2) -> (STAT1+STAT2+IRF9) => (IRF7,EIF2AK2)
  Expanded
(3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452,3456) -> (3454+3455) -> (3716,7297) -> (6772+6773+10379) => (3665,5610)
Class
nt06222 IFN signaling
nt06263 Hepatocellular carcinoma
nt06122 IFN signaling (viruses)
nt06169 Measles virus (MV)
nt06170 Influenza A virus (IAV)
nt06162 Hepatitis B virus (HBV)
nt06163 Hepatitis C virus (HCV)
nt06168 Herpes simplex virus 1 (HSV-1)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165 Epstein-Barr virus (EBV)
nt06166 Human papillomavirus (HPV)
Type
Reference
Pathway
hsa04620 Toll-like receptor signaling pathway   
Gene
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
3456  IFNB1; interferon beta 1
3454  IFNAR1; interferon alpha and beta receptor subunit 1
3455  IFNAR2; interferon alpha and beta receptor subunit 2
3716  JAK1; Janus kinase 1
7297  TYK2; tyrosine kinase 2
6772  STAT1; signal transducer and activator of transcription 1
6773  STAT2; signal transducer and activator of transcription 2
10379  IRF9; interferon regulatory factor 9
3665  IRF7; interferon regulatory factor 7
5610  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2
Reference
  Authors
Boo KH, Yang JS
  Title
Intrinsic cellular defenses against virus infection by antiviral type I interferon.
  Journal
Yonsei Med J 51:9-17 (2010)
DOI:10.3349/ymj.2010.51.1.9
Reference
  Authors
Ivashkiv LB, Donlin LT
  Title
Regulation of type I interferon responses.
  Journal
Nat Rev Immunol 14:36-49 (2014)
DOI:10.1038/nri3581
Reference
  Authors
Anders HJ, Lichtnekert J, Allam R
  Title
Interferon-alpha and -beta in kidney inflammation.
  Journal
Kidney Int 77:848-54 (2010)
DOI:10.1038/ki.2010.71
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