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Entry
N00153                      Network                                

Name
CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
Definition
(CC,CXC) -> (CCR,CXCR) -> GNB/G -> PI3Kgamma -> PREX1 -> RAC1
  Expanded
(6346,6347,6348,6351,3576) -> (1232,1233,1237,3579) -> (2782,2783,2784,59345,10681,54331,2785,2786,2787,2788,94235,2790,2791,55970,51764,2792,2793) -> (5294,23533,146850) -> 57580 -> 5879
Class
nt06224 CXCR signaling
nt06124 Chemokine signaling (viruses)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
hsa04062  Chemokine signaling pathway
Gene
6346  CCL1; C-C motif chemokine ligand 1
6347  CCL2; C-C motif chemokine ligand 2
6348  CCL3; C-C motif chemokine ligand 3
6351  CCL4; C-C motif chemokine ligand 4
3576  CXCL8; C-X-C motif chemokine ligand 8
1232  CCR3; C-C motif chemokine receptor 3
1233  CCR4; C-C motif chemokine receptor 4
1237  CCR8; C-C motif chemokine receptor 8
3579  CXCR2; C-X-C motif chemokine receptor 2
2782  GNB1; G protein subunit beta 1
2783  GNB2; G protein subunit beta 2
2784  GNB3; G protein subunit beta 3
59345  GNB4; G protein subunit beta 4
10681  GNB5; G protein subunit beta 5
54331  GNG2; G protein subunit gamma 2
2785  GNG3; G protein subunit gamma 3
2786  GNG4; G protein subunit gamma 4
2787  GNG5; G protein subunit gamma 5
2788  GNG7; G protein subunit gamma 7
94235  GNG8; G protein subunit gamma 8
2790  GNG10; G protein subunit gamma 10
2791  GNG11; G protein subunit gamma 11
55970  GNG12; G protein subunit gamma 12
51764  GNG13; G protein subunit gamma 13
2792  GNGT1; G protein subunit gamma transducin 1
2793  GNGT2; G protein subunit gamma transducin 2
5294  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
23533  PIK3R5; phosphoinositide-3-kinase regulatory subunit 5
146850  PIK3R6; phosphoinositide-3-kinase regulatory subunit 6
57580  PREX1; phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
5879  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Reference
  Authors
de Oliveira S, Rosowski EE, Huttenlocher A
  Title
Neutrophil migration in infection and wound repair: going forward in reverse.
  Journal
Nat Rev Immunol 16:378-91 (2016)
DOI:10.1038/nri.2016.49
Reference
  Authors
O'Hayre M, Salanga CL, Handel TM, Allen SJ
  Title
Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment.
  Journal
Biochem J 409:635-49 (2008)
DOI:10.1042/BJ20071493
Reference
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
  Authors
Ono SJ, Nakamura T, Miyazaki D, Ohbayashi M, Dawson M, Toda M
  Title
Chemokines: roles in leukocyte development, trafficking, and effector function.
  Journal
J Allergy Clin Immunol 111:1185-99; quiz 1200 (2003)
DOI:10.1067/mai.2003.1594
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