NETWORK: N00153
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Entry
N00153 Network
Name
CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
Definition
(CC,
CXC) -> (CCR,
CXCR) -> GNB/G -> PI3Kgamma -> PREX1 -> RAC1
Expanded
(6346,
6347,
6348,
6351,
3576) -> (1232,
1233,
1237,
3579) -> (2782,
2783,
2784,
59345,
10681,
54331,
2785,
2786,
2787,
2788,
94235,
2790,
2791,
55970,
51764,
2792,
2793) -> (5294,
23533,
146850) -> 57580 -> 5879
Class
nt06224
CXCR signaling
nt06124
Chemokine signaling (viruses)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
hsa04062
Chemokine signaling pathway
Gene
6346
CCL1; C-C motif chemokine ligand 1
6347
CCL2; C-C motif chemokine ligand 2
6348
CCL3; C-C motif chemokine ligand 3
6351
CCL4; C-C motif chemokine ligand 4
3576
CXCL8; C-X-C motif chemokine ligand 8
1232
CCR3; C-C motif chemokine receptor 3
1233
CCR4; C-C motif chemokine receptor 4
1237
CCR8; C-C motif chemokine receptor 8
3579
CXCR2; C-X-C motif chemokine receptor 2
2782
GNB1; G protein subunit beta 1
2783
GNB2; G protein subunit beta 2
2784
GNB3; G protein subunit beta 3
59345
GNB4; G protein subunit beta 4
10681
GNB5; G protein subunit beta 5
54331
GNG2; G protein subunit gamma 2
2785
GNG3; G protein subunit gamma 3
2786
GNG4; G protein subunit gamma 4
2787
GNG5; G protein subunit gamma 5
2788
GNG7; G protein subunit gamma 7
94235
GNG8; G protein subunit gamma 8
2790
GNG10; G protein subunit gamma 10
2791
GNG11; G protein subunit gamma 11
55970
GNG12; G protein subunit gamma 12
51764
GNG13; G protein subunit gamma 13
2792
GNGT1; G protein subunit gamma transducin 1
2793
GNGT2; G protein subunit gamma transducin 2
5294
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
23533
PIK3R5; phosphoinositide-3-kinase regulatory subunit 5
146850
PIK3R6; phosphoinositide-3-kinase regulatory subunit 6
57580
PREX1; phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
5879
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Reference
PMID:
27231052
Authors
de Oliveira S, Rosowski EE, Huttenlocher A
Title
Neutrophil migration in infection and wound repair: going forward in reverse.
Journal
Nat Rev Immunol 16:378-91 (2016)
DOI:
10.1038/nri.2016.49
Reference
PMID:
18177271
Authors
O'Hayre M, Salanga CL, Handel TM, Allen SJ
Title
Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment.
Journal
Biochem J 409:635-49 (2008)
DOI:
10.1042/BJ20071493
Reference
PMID:
11872087
Authors
Curnock AP, Logan MK, Ward SG
Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
Journal
Immunology 105:125-36 (2002)
DOI:
10.1046/j.1365-2567.2002.01345.x
Reference
PMID:
12789214
Authors
Ono SJ, Nakamura T, Miyazaki D, Ohbayashi M, Dawson M, Toda M
Title
Chemokines: roles in leukocyte development, trafficking, and effector function.
Journal
J Allergy Clin Immunol 111:1185-99; quiz 1200 (2003)
DOI:
10.1067/mai.2003.1594
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