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Entry
N00154                      Network                                

Name
CXCR-GNB/G-PI3K-AKT signaling pathway
Definition
CXCL8 -> CXCR2 -> GNB/G -> PI3Kgamma -> PIP3 -> AKT -> MTOR
  Expanded
3576 -> 3579 -> (2782,2783,2784,59345,10681,54331,2785,2786,2787,2788,94235,2790,2791,55970,51764,2792,2793) -> (5294,23533,146850) -> C05981 -> (207,208,10000) -> 2475
Class
nt06224 CXCR signaling
nt06124 Chemokine signaling (viruses)
nt06167 Human cytomegalovirus (HCMV)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
hsa04062  Chemokine signaling pathway
hsa04151  PI3K-Akt signaling pathway
Gene
3576  CXCL8; C-X-C motif chemokine ligand 8
3579  CXCR2; C-X-C motif chemokine receptor 2
2782  GNB1; G protein subunit beta 1
2783  GNB2; G protein subunit beta 2
2784  GNB3; G protein subunit beta 3
59345  GNB4; G protein subunit beta 4
10681  GNB5; G protein subunit beta 5
54331  GNG2; G protein subunit gamma 2
2785  GNG3; G protein subunit gamma 3
2786  GNG4; G protein subunit gamma 4
2787  GNG5; G protein subunit gamma 5
2788  GNG7; G protein subunit gamma 7
94235  GNG8; G protein subunit gamma 8
2790  GNG10; G protein subunit gamma 10
2791  GNG11; G protein subunit gamma 11
55970  GNG12; G protein subunit gamma 12
51764  GNG13; G protein subunit gamma 13
2792  GNGT1; G protein subunit gamma transducin 1
2793  GNGT2; G protein subunit gamma transducin 2
5294  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
23533  PIK3R5; phosphoinositide-3-kinase regulatory subunit 5
146850  PIK3R6; phosphoinositide-3-kinase regulatory subunit 6
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
O'Hayre M, Salanga CL, Handel TM, Allen SJ
  Title
Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment.
  Journal
Biochem J 409:635-49 (2008)
DOI:10.1042/BJ20071493
Reference
  Authors
Waugh DJ, Wilson C
  Title
The interleukin-8 pathway in cancer.
  Journal
Clin Cancer Res 14:6735-41 (2008)
DOI:10.1158/1078-0432.CCR-07-4843
Reference
  Authors
Campbell LM, Maxwell PJ, Waugh DJ
  Title
Rationale and Means to Target Pro-Inflammatory Interleukin-8 (CXCL8) Signaling in Cancer.
  Journal
Pharmaceuticals (Basel) 6:929-59 (2013)
DOI:10.3390/ph6080929
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