NETWORK: N00157
Entry
N00157 Network
Name
KSHV vGPCR to GNB/G-ERK signaling pathway
Definition
kshvGPCR -> GNB/G -> RAS -> RAF1 -> MEK -> ERK -> (HIF1A,
FOS,
JUN) => (VEGFA,
PDGFB,
ANGPT2)
Expanded
K21667 -> (2782,
2783,
2784,
59345,
10681,
54331,
2785,
2786,
2787,
2788,
94235,
2790,
2791,
55970,
51764,
2792,
2793) -> (3265,
3845,
4893) -> 5894 -> (5604,
5605) -> (5594,
5595) -> (3091,
2353,
3725) => (7422,
5155,
285)
Class
nt06224
CXCR signaling
nt06124
Chemokine signaling (viruses)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167
Kaposi sarcoma-associated herpesvirus infection
Disease
H00041
Kaposi sarcoma
Gene
2782
GNB1; G protein subunit beta 1
2783
GNB2; G protein subunit beta 2
2784
GNB3; G protein subunit beta 3
59345
GNB4; G protein subunit beta 4
10681
GNB5; G protein subunit beta 5
54331
GNG2; G protein subunit gamma 2
2785
GNG3; G protein subunit gamma 3
2786
GNG4; G protein subunit gamma 4
2787
GNG5; G protein subunit gamma 5
2788
GNG7; G protein subunit gamma 7
94235
GNG8; G protein subunit gamma 8
2790
GNG10; G protein subunit gamma 10
2791
GNG11; G protein subunit gamma 11
55970
GNG12; G protein subunit gamma 12
51764
GNG13; G protein subunit gamma 13
2792
GNGT1; G protein subunit gamma transducin 1
2793
GNGT2; G protein subunit gamma transducin 2
3265
HRAS; HRas proto-oncogene, GTPase
3845
KRAS; KRAS proto-oncogene, GTPase
4893
NRAS; NRAS proto-oncogene, GTPase
5894
RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604
MAP2K1; mitogen-activated protein kinase kinase 1
5605
MAP2K2; mitogen-activated protein kinase kinase 2
5594
MAPK1; mitogen-activated protein kinase 1
5595
MAPK3; mitogen-activated protein kinase 3
3091
HIF1A; hypoxia inducible factor 1 alpha subunit
2353
FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725
JUN; Jun proto-oncogene, AP-1 transcription factor subunit
7422
VEGFA; vascular endothelial growth factor A
5155
PDGFB; platelet derived growth factor subunit B
285
ANGPT2; angiopoietin 2
Perturbant
K21667
vGPCR; viral G-protein coupled receptor
Reference
PMID:
20865011
Authors
Mesri EA, Cesarman E, Boshoff C
Title
Kaposi's sarcoma and its associated herpesvirus.
Journal
Nat Rev Cancer 10:707-19 (2010)
DOI:
10.1038/nrc2888
Reference
PMID:
10987301
Authors
Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS
Title
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
Journal
Cancer Res 60:4873-80 (2000)
Reference
PMID:
27518127
Authors
Abere B, Schulz TF
Title
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
Journal
Curr Opin Virol 20:11-19 (2016)
DOI:
10.1016/j.coviro.2016.07.008
Reference
PMID:
15573137
Authors
Sodhi A, Montaner S, Gutkind JS
Title
Viral hijacking of G-protein-coupled-receptor signalling networks.
Journal
Nat Rev Mol Cell Biol 5:998-1012 (2004)
DOI:
10.1038/nrm1529
LinkDB
DBGET
integrated database retrieval system
