KEGG   NETWORK: N00161Help
Entry
N00161                      Network                                

Name
KSHV vIRF1/2 to TLR3-IRF3 signaling pathway
Definition
(kshvIRF1/2,kshvK8) -| IRF3 // (CREBBP,EP300) => IFNB1
  Expanded
(K21653,K21654,K21655) -| 3661 // (1387,2033) => 3456
Class
nt06221 TLR signaling
nt06121 TLR signaling (viruses and bacteria)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
3661  IRF3; interferon regulatory factor 3
1387  CREBBP; CREB binding protein
2033  EP300; E1A binding protein p300
3456  IFNB1; interferon beta 1
Perturbant
K21653  vIRF1, K9; KSHV interferon regulatory factor-like protein 1
K21654  vIRF2, K11; KSHV interferon regulatory factor-like protein 2
K21655  K8; KSHV E3 SUMO-protein ligase K-bZIP
Reference
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
  Authors
Coscoy L
  Title
Immune evasion by Kaposi's sarcoma-associated herpesvirus.
  Journal
Nat Rev Immunol 7:391-401 (2007)
DOI:10.1038/nri2076
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