KEGG   NETWORK: N00163Help
Entry
N00163                      Network                                

Name
KSHV KIE1/2 to TLR3-IRF7 signaling pathway
Definition
kshvKIE1/2 -| IRF7 => IFNA
  Expanded
(K21650,K21859) -| 3665 => (3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452)
Class
nt06221 TLR signaling
nt06121 TLR signaling (viruses and bacteria)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
3665  IRF7; interferon regulatory factor 7
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
Perturbant
K21650  KIE1, ORF50; KSHV transcription activator ORF50
K21859  KIE2, ORF45; KSHV transcription activator ORF45
Reference
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
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