KEGG   NETWORK: N00164Help
Entry
N00164                      Network                                

Name
KSHV vBCL2 to crosstalk between extrinsic and intrinsic apoptotic pathways
Definition
kshvBCL2 -| (BAX,BAK1) -> CYCS -- APAF1 -> CASP9 -> CASP3
  Expanded
K21660 -| (581,578) -> 54205 -- 317 -> 842 -> 836
Class
nt06231 Apoptosis
nt06131 Apoptosis (viruses and bacteria)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
581  BAX; BCL2 associated X, apoptosis regulator
578  BAK1; BCL2 antagonist/killer 1
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
Perturbant
K21660  vBCL2, ORF16; KSHV apoptosis regulator BCL2 homolog
Reference
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
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