KEGG   NETWORK: N00169Help
Entry
N00169                      Network                                

Name
KSHV LANA to p21-cell cycle G1/S
Definition
kshvLANA -| TP53 => CDKN1A -| CDK4/6 -> RB1 // E2F
  Expanded
K21664 -| 7157 => 1026 -| (1019,1021) -> 5925 // (1869,1870,1871)
Class
nt06230 Cell cycle G1/S
nt06130 Cell cycle (virus)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Virus
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
7157  TP53; tumor protein p53
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
1019  CDK4; cyclin dependent kinase 4
1021  CDK6; cyclin dependent kinase 6
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Perturbant
K21664  vLANA, ORF73; KSHV latency-associated nuclear antigen
Reference
  Authors
Schulz TF
  Title
Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8): epidemiology and pathogenesis.
  Journal
J Antimicrob Chemother 45 Suppl T3:15-27 (2000)
DOI:10.1093/jac/45.suppl_4.15
Reference
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
  Authors
Direkze S, Laman H
  Title
Regulation of growth signalling and cell cycle by Kaposi's sarcoma-associated herpesvirus genes.
  Journal
Int J Exp Pathol 85:305-19 (2004)
DOI:10.1111/j.0959-9673.2004.00407.x
Reference
  Authors
Mesri EA, Cesarman E, Boshoff C
  Title
Kaposi's sarcoma and its associated herpesvirus.
  Journal
Nat Rev Cancer 10:707-19 (2010)
DOI:10.1038/nrc2888
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