KEGG   NETWORK: N00172
Entry
N00172                      Network                                
Name
KSHV K15 to PLCG-calcineurin signaling pathway
Definition
K15 -> PLCG1
  Expanded
K21651 -> 5335
Class
nt06220 Calcium signaling (cancer)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
5335  PLCG1; phospholipase C gamma 1
Perturbant
K21651 (K15)  K15; KSHV signal transducing membrane protein
Reference
  Authors
Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Havemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF
  Title
Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
  Journal
PLoS Pathog 8:e1002927 (2012)
DOI:10.1371/journal.ppat.1002927
Reference
  Authors
Abere B, Schulz TF
  Title
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
  Journal
Curr Opin Virol 20:11-19 (2016)
DOI:10.1016/j.coviro.2016.07.008
Reference
  Authors
Hogan PG, Chen L, Nardone J, Rao A
  Title
Transcriptional regulation by calcium, calcineurin, and NFAT.
  Journal
Genes Dev 17:2205-32 (2003)
DOI:10.1101/gad.1102703
LinkDB

DBGET integrated database retrieval system