KEGG   NETWORK: N00173
Entry
N00173                      Network                                

Name
KSHV K15 to TNF-NFKB signaling pathway
Definition
K15 -> TRAF2 -> TAK1 -> IKK -> NFKBIA -> NFKB
  Expanded
K21651 -> 7186 -> 6885 -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06223 TNF signaling
nt06123 TNF signaling (viruses and bacteria)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
7186  TRAF2; TNF receptor associated factor 2
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Perturbant
K21651 (K15)  K15; KSHV signal transducing membrane protein
Reference
  Authors
Rahman MM, McFadden G
  Title
Modulation of NF-kappaB signalling by microbial pathogens.
  Journal
Nat Rev Microbiol 9:291-306 (2011)
DOI:10.1038/nrmicro2539
Reference
  Authors
Abere B, Schulz TF
  Title
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
  Journal
Curr Opin Virol 20:11-19 (2016)
DOI:10.1016/j.coviro.2016.07.008
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