KEGG   NETWORK: N00175Help
Entry
N00175                      Network                                

Name
KSHV LANA to Wnt signaling pathway
Definition
kshvLANA -| GSK3B -| CTNNB1 -> TCF/LEF => CCND1
  Expanded
K21664 -| 2932 -| 1499 -> (6932,83439,6934,51176) => 595
Class
nt06215 WNT signaling
nt06115 WNT signaling (viruses)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
2932  GSK3B; glycogen synthase kinase 3 beta
1499  CTNNB1; catenin beta 1
6932  TCF7; transcription factor 7
83439  TCF7L1; transcription factor 7 like 1
6934  TCF7L2; transcription factor 7 like 2
51176  LEF1; lymphoid enhancer binding factor 1
595  CCND1; cyclin D1
Perturbant
K21664  vLANA, ORF73; KSHV latency-associated nuclear antigen
Reference
  Authors
Fujimuro M, Wu FY, ApRhys C, Kajumbula H, Young DB, Hayward GS, Hayward SD
  Title
A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency.
  Journal
Nat Med 9:300-6 (2003)
DOI:10.1038/nm829
Reference
  Authors
Fujimuro M, Hayward SD
  Title
Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
  Journal
J Mol Med (Berl) 82:223-31 (2004)
DOI:10.1007/s00109-003-0519-7
Reference
  Authors
Purushothaman P, Dabral P, Gupta N, Sarkar R, Verma SC
  Title
KSHV Genome Replication and Maintenance.
  Journal
Front Microbiol 7:54 (2016)
DOI:10.3389/fmicb.2016.00054
Reference
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
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