KEGG   NETWORK: N00181
Entry
N00181                      Network                                

Name
KSHV vIL-6 to Jak-STAT signaling pathway
Definition
vIL6 -> IL6ST -> JAK2 -> STAT3
  Expanded
K21670 -> 3572 -> 3717 -> 6774
Class
nt06219 JAK-STAT signaling
nt06119 JAK-STAT signaling (viruses)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
3572  IL6ST; interleukin 6 signal transducer
3717  JAK2; Janus kinase 2
6774  STAT3; signal transducer and activator of transcription 3
Perturbant
K21670 (vIL6)  vIL6; KSHV interleukin 6
Reference
  Authors
Wu J, Xu Y, Mo D, Huang P, Sun R, Huang L, Pan S, Xu J
  Title
Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 promotes cell proliferation and migration by upregulating DNMT1 via STAT3 activation.
  Journal
PLoS One 9:e93478 (2014)
DOI:10.1371/journal.pone.0093478
Reference
  Authors
Sodhi A, Montaner S, Gutkind JS
  Title
Viral hijacking of G-protein-coupled-receptor signalling networks.
  Journal
Nat Rev Mol Cell Biol 5:998-1012 (2004)
DOI:10.1038/nrm1529
Reference
  Authors
Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M
  Title
The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
  Journal
Virology 428:112-20 (2012)
DOI:10.1016/j.virol.2012.03.013
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