KEGG   NETWORK: N00185Help
Entry
N00185                      Network                                

Name
KSHV MIR2 to cell surface molecule-endocytosis
Definition
kshvMIR2 -| (ICAM1,CD86,MICA,MICB,CLEC2B,IFNGR1)
  Expanded
K21666 -| (3383,942,100507436,4277,9976,3459)
Class
nt06229 MHC presentation
nt06129 MHC presentation (viruses)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
3383  ICAM1; intercellular adhesion molecule 1
942  CD86; CD86 molecule
100507436  MICA; MHC class I polypeptide-related sequence A
4277  MICB; MHC class I polypeptide-related sequence B
9976  CLEC2B; C-type lectin domain family 2 member B
3459  IFNGR1; interferon gamma receptor 1
Perturbant
K21666  MIR2, K5; KSHV E3 ubiquitin-protein ligase MIR2
Reference
  Authors
Ishido S, Choi JK, Lee BS, Wang C, DeMaria M, Johnson RP, Cohen GB, Jung JU
  Title
Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein.
  Journal
Immunity 13:365-74 (2000)
DOI:10.1016/S1074-7613(00)00036-4
Reference
  Authors
Coscoy L, Ganem D
  Title
A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
  Journal
J Clin Invest 107:1599-606 (2001)
DOI:10.1172/JCI12432
Reference
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
  Authors
Thomas M, Boname JM, Field S, Nejentsev S, Salio M, Cerundolo V, Wills M, Lehner PJ
  Title
Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
  Journal
Proc Natl Acad Sci U S A 105:1656-61 (2008)
DOI:10.1073/pnas.0707883105
Reference
  Authors
Li Q, Means R, Lang S, Jung JU
  Title
Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
  Journal
J Virol 81:2117-27 (2007)
DOI:10.1128/JVI.01961-06
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