KEGG   NETWORK: N00186Help
Entry
N00186                      Network                                

Name
IL1-IL1R-p38 signaling pathway
Definition
IL1 -> IL1R -> MYD88 -> IRAK1/4 -> TRAF6 -> TAB1/2/3 -> TAK1 -> MKK3/6 -> MAPK14 -> MK2 -| TTP
  Expanded
(3552,3553) -> (3554+3556) -> 4615 -> (3654,51135) -> 7189 -> (10454,23118,257397) -> 6885 -> (5606,5608) -> 1432 -> 9261 -| 7538
Class
nt06211 Other MAPK signaling
nt06110 MAPK signaling (viruses)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
hsa04010  MAPK signaling pathway
Gene
3552  IL1A; interleukin 1 alpha
3553  IL1B; interleukin 1 beta
3554  IL1R1; interleukin 1 receptor type 1
3556  IL1RAP; interleukin 1 receptor accessory protein
4615  MYD88; myeloid differentiation primary response 88
3654  IRAK1; interleukin 1 receptor associated kinase 1
51135  IRAK4; interleukin 1 receptor associated kinase 4
7189  TRAF6; TNF receptor associated factor 6
10454  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1
23118  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2
257397  TAB3; TGF-beta activated kinase 1 and MAP3K7 binding protein 3
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
5606  MAP2K3; mitogen-activated protein kinase kinase 3
5608  MAP2K6; mitogen-activated protein kinase kinase 6
1432  MAPK14; mitogen-activated protein kinase 14
9261  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
7538  ZFP36; ZFP36 ring finger protein
Reference
  Authors
Kulawik A, Engesser R, Ehlting C, Raue A, Albrecht U, Hahn B, Lehmann WD, Gaestel M, Klingmuller U, Haussinger D, Timmer J, Bode JG
  Title
IL-1beta-induced and p38MAPK-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification.
  Journal
J Biol Chem 292:6291-6302 (2017)
DOI:10.1074/jbc.M117.775023
Reference
  Authors
Winzen R, Thakur BK, Dittrich-Breiholz O, Shah M, Redich N, Dhamija S, Kracht M, Holtmann H
  Title
Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets.
  Journal
Mol Cell Biol 27:8388-400 (2007)
DOI:10.1128/MCB.01493-07
Reference
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
  Authors
de Nadal E, Ammerer G, Posas F
  Title
Controlling gene expression in response to stress.
  Journal
Nat Rev Genet 12:833-45 (2011)
DOI:10.1038/nrg3055
Reference
  Authors
Thapar R, Denmon AP
  Title
Signaling pathways that control mRNA turnover.
  Journal
Cell Signal 25:1699-710 (2013)
DOI:10.1016/j.cellsig.2013.03.026
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