KEGG   NETWORK: N00189Help
Entry
N00189                      Network                                

Name
KSHV K15 to JNK signaling pathway
Definition
kshvK15 -> MKK4/7 -> JNK -> AP1
  Expanded
K21651 -> (6416,5609) -> (5599,5601,5602) -> (2353,3725)
Class
nt06211 Other MAPK signaling
nt06110 MAPK signaling (viruses)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
6416  MAP2K4; mitogen-activated protein kinase kinase 4
5609  MAP2K7; mitogen-activated protein kinase kinase 7
5599  MAPK8; mitogen-activated protein kinase 8
5601  MAPK9; mitogen-activated protein kinase 9
5602  MAPK10; mitogen-activated protein kinase 10
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit
Perturbant
K21651  K15; signal transducing membrane protein
Reference
  Authors
Abere B, Schulz TF
  Title
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
  Journal
Curr Opin Virol 20:11-19 (2016)
DOI:10.1016/j.coviro.2016.07.008
Reference
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
  Authors
Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF
  Title
Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
  Journal
J Virol 81:42-58 (2007)
DOI:10.1128/JVI.00648-06
Reference
  Authors
Brinkmann MM, Glenn M, Rainbow L, Kieser A, Henke-Gendo C, Schulz TF
  Title
Activation of mitogen-activated protein kinase and NF-kappaB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein.
  Journal
J Virol 77:9346-58 (2003)
DOI:10.1128/JVI.77.17.9346-9358.2003
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