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Entry
N00216                      Network                                

Name
HGF-MET-RAS-ERK signaling pathway
Definition
HGF -> MET -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
3082 -> 4233 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06210 ERK signaling
nt06261 Gastric cancer
nt06262 Pancreatic cancer
nt06263 Hepatocellular carcinoma
nt06264 Renal cell carcinoma
nt06110 MAPK signaling (virus)
nt06170 Influenza A virus (IAV)
nt06162 Hepatitis B virus (HBV)
nt06163 Hepatitis C virus (HCV)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
hsa04014  Ras signaling pathway
Gene
3082  HGF; hepatocyte growth factor
4233  MET; MET proto-oncogene, receptor tyrosine kinase
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Reference
  Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
  Title
Met, metastasis, motility and more.
  Journal
Nat Rev Mol Cell Biol 4:915-25 (2003)
DOI:10.1038/nrm1261
Reference
  Authors
Bradley CA, Salto-Tellez M, Laurent-Puig P, Bardelli A, Rolfo C, Tabernero J, Khawaja HA, Lawler M, Johnston PG, Van Schaeybroeck S
  Title
Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges.
  Journal
Nat Rev Clin Oncol 14:562-576 (2017)
DOI:10.1038/nrclinonc.2017.40
Reference
  Authors
Parikh RA, Wang P, Beumer JH, Chu E, Appleman LJ
  Title
The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment.
  Journal
Onco Targets Ther 7:969-83 (2014)
DOI:10.2147/OTT.S40241
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