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Entry
N00222                      Network                                

Name
HTLV-1 Tax to spindle assembly checkpoint signaling
Definition
htlvTAX -| MAD1L1 -> (MAD2L1/2+BUB1B+BUB3) -| (ANAPC+CDC20) -| PTTG -| ESPL1
  Expanded
K21857 -| 8379 -> ((4085,10459)+701+9184) -| ((64682,29882,996,29945,51433,8881,51434,10393,51529,246184,25847,8697)+991) -| (9232,10744) -| 9700
Class
nt06230 Cell cycle G1/S
nt06130 Cell cycle (virus)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Virus
Pathway
hsa05166  Human T-cell leukemia virus 1 infection
Disease
H00009  Adult T-cell leukemia
Gene
8379  MAD1L1; MAD1 mitotic arrest deficient like 1
4085  MAD2L1; mitotic arrest deficient 2 like 1
10459  MAD2L2; mitotic arrest deficient 2 like 2
701  BUB1B; BUB1 mitotic checkpoint serine/threonine kinase B
9184  BUB3; BUB3, mitotic checkpoint protein
64682  ANAPC1; anaphase promoting complex subunit 1
29882  ANAPC2; anaphase promoting complex subunit 2
996  CDC27; cell division cycle 27
29945  ANAPC4; anaphase promoting complex subunit 4
51433  ANAPC5; anaphase promoting complex subunit 5
8881  CDC16; cell division cycle 16
51434  ANAPC7; anaphase promoting complex subunit 7
10393  ANAPC10; anaphase promoting complex subunit 10
51529  ANAPC11; anaphase promoting complex subunit 11
246184  CDC26; cell division cycle 26
25847  ANAPC13; anaphase promoting complex subunit 13
8697  CDC23; cell division cycle 23
991  CDC20; cell division cycle 20
9232  PTTG1; pituitary tumor-transforming 1
10744  PTTG2; pituitary tumor-transforming 2
9700  ESPL1; extra spindle pole bodies like 1, separase
Perturbant
K21857  tax; protein Tax-1
Reference
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
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