KEGG   NETWORK: N00227Help
Entry
N00227                      Network                                

Name
TGFA-EGFR-PLCG-PKC signaling pathway
Definition
TGFA -> EGFR -> PLCG -> (Ca2+,DAG) -> PKC -> ELK1
  Expanded
7039 -> 1956 -> (5335,5336) -> (C00076,C00165) -> (5578,5579,5582) -> 2002
Class
nt06220 Calcium signaling
nt06263 Hepatocellular carcinoma
Type
Reference
Pathway
hsa04020  Calcium signaling pathway
Gene
7039  TGFA; transforming growth factor alpha
1956  EGFR; epidermal growth factor receptor
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
5578  PRKCA; protein kinase C alpha
5579  PRKCB; protein kinase C beta
5582  PRKCG; protein kinase C gamma
2002  ELK1; ELK1, ETS transcription factor
Reference
  Authors
Mascia F, Denning M, Kopan R, Yuspa SH
  Title
The black box illuminated: signals and signaling.
  Journal
J Invest Dermatol 132:811-9 (2012)
DOI:10.1038/jid.2011.406
Reference
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
  Authors
Chong CR, Janne PA
  Title
The quest to overcome resistance to EGFR-targeted therapies in cancer.
  Journal
Nat Med 19:1389-400 (2013)
DOI:10.1038/nm.3388
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