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Entry
N00240                      Network                                

Name
TERT-overexpression to telomerase activity
Definition
(TERT*+TERC) -> DNA
  Expanded
(7015v1+7012) -> C00039
Class
nt06232 Telomerase activity
nt06261 Gastric cancer
nt06263 Hepatocellular carcinoma
Type
Variant
Pathway
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Disease
H00048  Hepatocellular carcinoma
H00018  Gastric cancer
Gene
7015  TERT; telomerase reverse transcriptase
7012  TERC; telomerase RNA component
Variant
7015v1  TERT overexpression
Reference
  Authors
Shay JW, Wright WE
  Title
Role of telomeres and telomerase in cancer.
  Journal
Semin Cancer Biol 21:349-53 (2011)
DOI:10.1016/j.semcancer.2011.10.001
Reference
  Authors
Jafri MA, Ansari SA, Alqahtani MH, Shay JW
  Title
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.
  Journal
Genome Med 8:69 (2016)
DOI:10.1186/s13073-016-0324-x
Reference
  Authors
Krupp G, Bonatz G, Parwaresch R
  Title
Telomerase, immortality and cancer.
  Journal
Biotechnol Annu Rev 6:103-40 (2000)
DOI:10.1016/S1387-2656(00)06020-8
Reference
  Authors
Mu J, Wei LX
  Title
Telomere and telomerase in oncology.
  Journal
Cell Res 12:1-7 (2002)
DOI:10.1038/sj.cr.7290104
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