KEGG   NETWORK: N00242Help
Entry
N00242                      Network                                

Name
Mutation-inactivated AXIN to Wnt signaling pathway
Definition
(GSK3B+APC) // AXIN* // CTNNB1 -> TCF/LEF => (MYC,CCND1)
  Expanded
(2932+324) // 8312v1 // 1499 -> (6932,83439,6934,51176) => (4609,595)
Class
nt06215 WNT signaling
nt06263 Hepatocellular carcinoma
Type
Variant
Pathway
hsa05225  Hepatocellular carcinoma
Disease
H00048  Hepatocellular carcinoma
Gene
2932  GSK3B; glycogen synthase kinase 3 beta
324  APC; APC, WNT signaling pathway regulator
8312  AXIN1; axin 1
1499  CTNNB1; catenin beta 1
6932  TCF7; transcription factor 7
83439  TCF7L1; transcription factor 7 like 1
6934  TCF7L2; transcription factor 7 like 2
51176  LEF1; lymphoid enhancer binding factor 1
4609  MYC; MYC proto-oncogene, bHLH transcription factor
595  CCND1; cyclin D1
Variant
8312v1  AXIN1 mutation
Reference
  Authors
Polakis P
  Title
Wnt signaling in cancer.
  Journal
Cold Spring Harb Perspect Biol 4:a008052 (2012)
DOI:10.1101/cshperspect.a008052
Reference
  Authors
Salahshor S, Woodgett JR
  Title
The links between axin and carcinogenesis.
  Journal
J Clin Pathol 58:225-36 (2005)
DOI:10.1136/jcp.2003.009506
Reference
  Authors
Taniguchi K, Roberts LR, Aderca IN, Dong X, Qian C, Murphy LM, Nagorney DM, Burgart LJ, Roche PC, Smith DI, Ross JA, Liu W
  Title
Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas.
  Journal
Oncogene 21:4863-71 (2002)
DOI:10.1038/sj.onc.1205591
Reference
  Authors
Mazzoni SM, Fearon ER
  Title
AXIN1 and AXIN2 variants in gastrointestinal cancers.
  Journal
Cancer Lett 355:1-8 (2014)
DOI:10.1016/j.canlet.2014.09.018
Reference
  Authors
Kumar M, Zhao X, Wang XW
  Title
Molecular carcinogenesis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: one step closer to personalized medicine?
  Journal
Cell Biosci 1:5 (2011)
DOI:10.1186/2045-3701-1-5
Reference
  Authors
Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM.
  Title
Genomics and signaling pathways in hepatocellular carcinoma.
  Journal
Semin Liver Dis 27:55-76 (2007)
DOI:10.1055/s-2006-960171
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