KEGG   NETWORK: N00243Help
Entry
N00243                      Network                                

Name
KEAP1-NRF2 signaling pathway
Definition
(O2-,HO2,H2O2,OH,ACRL,4HNE,NO) -| KEAP1 -| NRF2 => (HMOX1,NQO1,GST,TXNRD1)
  Expanded
(C00704,C21641,C00027,C16844,C01471,C21642,C00533) -| 9817 -| 4780 => (3162,1728,119391,221357,2938,2939,2940,2941,2944,2946,2947,2948,2949,2950,2952,2953,4257,4258,4259,653689,9446,7296)
Class
nt06226 KEAP1-NRF2 signaling
nt06263 Hepatocellular carcinoma
Type
Reference
Gene
9817  KEAP1; kelch like ECH associated protein 1
4780  NFE2L2; nuclear factor, erythroid 2 like 2
3162  HMOX1; heme oxygenase 1
1728  NQO1; NAD(P)H quinone dehydrogenase 1
119391  GSTO2; glutathione S-transferase omega 2
221357  GSTA5; glutathione S-transferase alpha 5
2938  GSTA1; glutathione S-transferase alpha 1
2939  GSTA2; glutathione S-transferase alpha 2
2940  GSTA3; glutathione S-transferase alpha 3
2941  GSTA4; glutathione S-transferase alpha 4
2944  GSTM1; glutathione S-transferase mu 1
2946  GSTM2; glutathione S-transferase mu 2
2947  GSTM3; glutathione S-transferase mu 3
2948  GSTM4; glutathione S-transferase mu 4
2949  GSTM5; glutathione S-transferase mu 5
2950  GSTP1; glutathione S-transferase pi 1
2952  GSTT1; glutathione S-transferase theta 1
2953  GSTT2; glutathione S-transferase theta 2 (gene/pseudogene)
4257  MGST1; microsomal glutathione S-transferase 1
4258  MGST2; microsomal glutathione S-transferase 2
4259  MGST3; microsomal glutathione S-transferase 3
653689  GSTT2B; glutathione S-transferase theta 2B (gene/pseudogene)
9446  GSTO1; glutathione S-transferase omega 1
7296  TXNRD1; thioredoxin reductase 1
Metabolite
C00704  O2.-
C21641  Hydroperoxyl radical
C00027  Hydrogen peroxide
C16844  Hydroxyl radical
C01471  Acrolein
C21642  4-Hydroxynonenal
C00533  Nitric oxide
Reference
  Authors
Taguchi K, Motohashi H, Yamamoto M
  Title
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution.
  Journal
Genes Cells 16:123-40 (2011)
DOI:10.1111/j.1365-2443.2010.01473.x
Reference
  Authors
McMahon M, Lamont DJ, Beattie KA, Hayes JD
  Title
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals.
  Journal
Proc Natl Acad Sci U S A 107:18838-43 (2010)
DOI:10.1073/pnas.1007387107
Reference
  Authors
Ganan-Gomez I, Wei Y, Yang H, Boyano-Adanez MC, Garcia-Manero G
  Title
Oncogenic functions of the transcription factor Nrf2.
  Journal
Free Radic Biol Med 65:750-64 (2013)
DOI:10.1016/j.freeradbiomed.2013.06.041
Reference
  Authors
Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL
  Title
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.
  Journal
Redox Biol 1:45-9 (2013)
DOI:10.1016/j.redox.2012.10.001
Reference
  Authors
Kim HJ, Vaziri ND
  Title
Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure.
  Journal
Am J Physiol Renal Physiol 298:F662-71 (2010)
DOI:10.1152/ajprenal.00421.2009
Reference
  Authors
Praslicka BJ, Kerins MJ, Ooi A
  Title
The complex role of NRF2 in cancer: a genomic view
  Journal
Current Opinion in Toxicology 1:37-45 (2016)
DOI:10.1016/j.cotox.2016.09.003
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