KEGG   NETWORK: N00244Help
Entry
N00244                      Network                                

Name
Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
Definition
KEAP1* // NRF2 => (HMOX1,NQO1,GST,TXNRD1)
  Expanded
9817v1 // 4780 => (3162,1728,119391,221357,2938,2939,2940,2941,2944,2946,2947,2948,2949,2950,2952,2953,4257,4258,4259,653689,9446,7296)
Class
nt06226 KEAP1-NRF2 signaling
nt06263 Hepatocellular carcinoma
Type
Variant
Pathway
hsa05225  Hepatocellular carcinoma
Disease
H00048  Hepatocellular carcinoma
Gene
9817  KEAP1; kelch like ECH associated protein 1
4780  NFE2L2; nuclear factor, erythroid 2 like 2
3162  HMOX1; heme oxygenase 1
1728  NQO1; NAD(P)H quinone dehydrogenase 1
119391  GSTO2; glutathione S-transferase omega 2
221357  GSTA5; glutathione S-transferase alpha 5
2938  GSTA1; glutathione S-transferase alpha 1
2939  GSTA2; glutathione S-transferase alpha 2
2940  GSTA3; glutathione S-transferase alpha 3
2941  GSTA4; glutathione S-transferase alpha 4
2944  GSTM1; glutathione S-transferase mu 1
2946  GSTM2; glutathione S-transferase mu 2
2947  GSTM3; glutathione S-transferase mu 3
2948  GSTM4; glutathione S-transferase mu 4
2949  GSTM5; glutathione S-transferase mu 5
2950  GSTP1; glutathione S-transferase pi 1
2952  GSTT1; glutathione S-transferase theta 1
2953  GSTT2; glutathione S-transferase theta 2 (gene/pseudogene)
4257  MGST1; microsomal glutathione S-transferase 1
4258  MGST2; microsomal glutathione S-transferase 2
4259  MGST3; microsomal glutathione S-transferase 3
653689  GSTT2B; glutathione S-transferase theta 2B (gene/pseudogene)
9446  GSTO1; glutathione S-transferase omega 1
7296  TXNRD1; thioredoxin reductase 1
Variant
9817v1  KEAP1 mutation
Reference
  Authors
Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL
  Title
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.
  Journal
Redox Biol 1:45-9 (2013)
DOI:10.1016/j.redox.2012.10.001
Reference
  Authors
Praslicka BJ, Kerins MJ, Ooi A
  Title
The complex role of NRF2 in cancer: a genomic view
  Journal
Current Opinion in Toxicology 1:37-45 (2016)
DOI:10.1016/j.cotox.2016.09.003
Reference
  Authors
Nault JC, Rebouissou S, Zucman Rossi J
  Title
NRF2/KEAP1 and Wnt/beta-catenin in the multistep process of liver carcinogenesis in humans and rats.
  Journal
Hepatology 62:677-9 (2015)
DOI:10.1002/hep.27828
LinkDB All DBs

DBGET integrated database retrieval system