KEGG   NETWORK: N00248Help
Entry
N00248                      Network                                

Name
MET-overexpression to RAS-ERK signaling pathway
Definition
MET* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
4233v2 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06210 ERK signaling
nt06263 Hepatocellular carcinoma
Type
Variant
Pathway
hsa05225  Hepatocellular carcinoma
Disease
H00048  Hepatocellular carcinoma
Gene
4233  MET; MET proto-oncogene, receptor tyrosine kinase
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Variant
4233v2  MET overexpression
Reference
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
  Authors
Granito A, Guidetti E, Gramantieri L
  Title
c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma.
  Journal
J Hepatocell Carcinoma 2:29-38 (2015)
DOI:10.2147/JHC.S77038
Reference
  Authors
Wickramasinghe D, Kong-Beltran M
  Title
Met activation and receptor dimerization in cancer: a role for the Sema domain.
  Journal
Cell Cycle 4:683-5 (2005)
DOI:10.4161/cc.4.5.1688
Reference
  Authors
Gao CF, Vande Woude GF
  Title
HGF/SF-Met signaling in tumor progression.
  Journal
Cell Res 15:49-51 (2005)
DOI:10.1038/sj.cr.7290264
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