KEGG   NETWORK: N00249Help
Entry
N00249                      Network                                

Name
MET-overexpression to PI3K signaling pathway
Definition
MET* -> GAB1 -> PI3K -> PIP3 -> AKT -| BAD
  Expanded
4233v2 -> 2549 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572
Class
nt06214 PI3K signaling
nt06263 Hepatocellular carcinoma
Type
Variant
Pathway
hsa05225  Hepatocellular carcinoma
Disease
H00048  Hepatocellular carcinoma
Gene
4233  MET; MET proto-oncogene, receptor tyrosine kinase
2549  GAB1; GRB2 associated binding protein 1
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
572  BAD; BCL2 associated agonist of cell death
Variant
4233v2  MET overexpression
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
  Authors
Granito A, Guidetti E, Gramantieri L
  Title
c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma.
  Journal
J Hepatocell Carcinoma 2:29-38 (2015)
DOI:10.2147/JHC.S77038
Reference
  Authors
Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM.
  Title
Genomics and signaling pathways in hepatocellular carcinoma.
  Journal
Semin Liver Dis 27:55-76 (2007)
DOI:10.1055/s-2006-960171
Reference
  Authors
Wickramasinghe D, Kong-Beltran M
  Title
Met activation and receptor dimerization in cancer: a role for the Sema domain.
  Journal
Cell Cycle 4:683-5 (2005)
DOI:10.4161/cc.4.5.1688
Reference
  Authors
Gao CF, Vande Woude GF
  Title
HGF/SF-Met signaling in tumor progression.
  Journal
Cell Res 15:49-51 (2005)
DOI:10.1038/sj.cr.7290264
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