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Entry
N00250                      Network                                

Name
CDX2-overexpression to transcriptional activation
Definition
CDX2* => (MUC2,CDH17,REG4,ABCB1)
  Expanded
1045v1 => (4583,1015,83998,5243)
Class
nt06240 Transcription
nt06261 Gastric cancer
Type
Variant
Pathway
hsa05226  Gastric cancer
Disease
H00018  Gastric cancer
Gene
1045  CDX2; caudal type homeobox 2
4583  MUC2; mucin 2, oligomeric mucus/gel-forming
1015  CDH17; cadherin 17
83998  REG4; regenerating family member 4
5243  ABCB1; ATP binding cassette subfamily B member 1
Variant
1045v1  CDX2 overexpression
Reference
  Authors
Almeida R, Silva E, Santos-Silva F, Silberg DG, Wang J, De Bolos C, David L
  Title
Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas.
  Journal
J Pathol 199:36-40 (2003)
DOI:10.1002/path.1246
Reference
  Authors
Tan P, Yeoh KG
  Title
Genetics and Molecular Pathogenesis of Gastric Adenocarcinoma.
  Journal
Gastroenterology 149:1153-1162.e3 (2015)
DOI:10.1053/j.gastro.2015.05.059
Reference
  Authors
Yuasa Y
  Title
Control of gut differentiation and intestinal-type gastric carcinogenesis.
  Journal
Nat Rev Cancer 3:592-600 (2003)
DOI:10.1038/nrc1141
Reference
  Authors
Vauhkonen M, Vauhkonen H, Sipponen P
  Title
Pathology and molecular biology of gastric cancer.
  Journal
Best Pract Res Clin Gastroenterol 20:651-74 (2006)
DOI:10.1016/j.bpg.2006.03.016
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