KEGG   NETWORK: N00254
Entry
N00254                      Network                                

Name
CDKN1B-reduced expression to p27-cell cycle G1/S
Definition
CDKN1B* // (CCNE+CDK2) -> RB1 // E2F
  Expanded
1027v2 // ((898,9134)+1017) -> 5925 // (1869,1870,1871)
Class
nt06230 Cell cycle G1/S
nt06261 Gastric cancer
Type
Variant
Pathway
hsa05226  Gastric cancer
Disease
H00018  Gastric cancer
Gene
1027  CDKN1B; cyclin dependent kinase inhibitor 1B
898  CCNE1; cyclin E1
9134  CCNE2; cyclin E2
1017  CDK2; cyclin dependent kinase 2
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Variant
1027v2 (CDKN1B*)  CDKN1B reduced expression
Reference
  Authors
Kim DH, Lee HI, Nam ES, Shin HS, Sohn JH, Park CH, Yoon DS, Song SY, Park YE
  Title
Reduced expression of the cell-cycle inhibitor p27Kip1 is associated with progression and lymph node metastasis of gastric carcinoma.
  Journal
Histopathology 36:245-51 (2000)
DOI:10.1046/j.1365-2559.2000.00842.x
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