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Entry
N00254                      Network                                

Name
CDKN1B-reduced expression to p27-cell cycle G1/S
Definition
CDKN1B* // (CCNE+CDK2) -> RB1 // E2F
  Expanded
1027v2 // ((898,9134)+1017) -> 5925 // (1869,1870,1871)
Class
nt06230 Cell cycle G1/S
nt06261 Gastric cancer
Type
Variant
Pathway
hsa05226  Gastric cancer
Disease
H00018  Gastric cancer
Gene
1027  CDKN1B; cyclin dependent kinase inhibitor 1B
898  CCNE1; cyclin E1
9134  CCNE2; cyclin E2
1017  CDK2; cyclin dependent kinase 2
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Variant
1027v2  CDKN1B reduced expression
Reference
  Authors
Kim DH, Lee HI, Nam ES, Shin HS, Sohn JH, Park CH, Yoon DS, Song SY, Park YE
  Title
Reduced expression of the cell-cycle inhibitor p27Kip1 is associated with progression and lymph node metastasis of gastric carcinoma.
  Journal
Histopathology 36:245-51 (2000)
DOI:10.1046/j.1365-2559.2000.00842.x
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