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Entry
N00263                      Network                                

Name
EBV EBNA3C to p53-mediated transcription
Definition
ebvEBNA3C -> MDM2 -| TP53 => (CDKN1A,GADD45,BAX,BAK1,DDB2,POLK)
  Expanded
K19458 -> 4193 -| 7157 => (1026,1647,4616,10912,581,578,1643,51426)
Class
nt06165 Epstein-Barr virus (EBV)
Type
Virus
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
4193  MDM2; MDM2 proto-oncogene
7157  TP53; tumor protein p53
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
1647  GADD45A; growth arrest and DNA damage inducible alpha
4616  GADD45B; growth arrest and DNA damage inducible beta
10912  GADD45G; growth arrest and DNA damage inducible gamma
581  BAX; BCL2 associated X, apoptosis regulator
578  BAK1; BCL2 antagonist/killer 1
1643  DDB2; damage specific DNA binding protein 2
51426  POLK; DNA polymerase kappa
Perturbant
K19458  EBNA6; Epstein-Barr nuclear antigen 6
Reference
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
  Authors
Maruo S, Johannsen E, Illanes D, Cooper A, Zhao B, Kieff E
  Title
Epstein-Barr virus nuclear protein 3A domains essential for growth of lymphoblasts: transcriptional regulation through RBP-Jkappa/CBF1 is critical.
  Journal
J Virol 79:10171-9 (2005)
DOI:10.1128/JVI.79.16.10171-10179.2005
Reference
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
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