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Entry
N00264                      Network                                

Name
EBV EBNA3C to p27-Cell cycle G1/S
Definition
ebvEBNA3C -> SKP2 -| CDKN1B -| ((CCNA,CCNE)+CDK2) -> RB1 // E2F
  Expanded
K19458 -> 6502 -| 1027 -| ((890,8900,898,9134)+1017) -> 5925 // (1869,1870,1871)
Class
nt06130 Cell cycle (virus)
nt06165 Epstein-Barr virus (EBV)
Type
Virus
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
6502  SKP2; S-phase kinase associated protein 2
1027  CDKN1B; cyclin dependent kinase inhibitor 1B
890  CCNA2; cyclin A2
8900  CCNA1; cyclin A1
898  CCNE1; cyclin E1
9134  CCNE2; cyclin E2
1017  CDK2; cyclin dependent kinase 2
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Perturbant
K19458  EBNA6; Epstein-Barr nuclear antigen 6
Reference
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
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