KEGG   NETWORK: N00266
Entry
N00266                      Network                                

Name
EBV LMP2A to PI3K signaling pathway
Definition
LMP2A -- (LYN,SYK) -> PI3K -> PIP3 -> AKT
  Expanded
K19460 -- (4067,6850) -> (5290,5291,5293) -> C05981 -> (207,208,10000)
Class
nt06114 PI3K signaling (viruses)
nt06165 Epstein-Barr virus (EBV)
Type
Pathogen
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
4067  LYN; LYN proto-oncogene, Src family tyrosine kinase
6850  SYK; spleen associated tyrosine kinase
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Perturbant
K19460 (LMP2A)  LMP2A; EBV latent membrane protein 2A
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
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