KEGG   NETWORK: N00270Help
Entry
N00270                      Network                                

Name
HCV Core to IFN signaling pathway
Definition
hcvCore -| (STAT1+STAT2+IRF9) => (OAS,EIF2AK,MX1)
  Expanded
K22271 -| (6772+6773+10379) => (4938,4939,4940,27102,5610,9451,440275,4599)
Class
nt06222 IFN signaling
nt06263 Hepatocellular carcinoma
nt06122 IFN signaling (viruses)
nt06163 Hepatitis C virus (HCV)
Type
Pathogen
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
6772  STAT1; signal transducer and activator of transcription 1
6773  STAT2; signal transducer and activator of transcription 2
10379  IRF9; interferon regulatory factor 9
4938  OAS1; 2'-5'-oligoadenylate synthetase 1
4939  OAS2; 2'-5'-oligoadenylate synthetase 2
4940  OAS3; 2'-5'-oligoadenylate synthetase 3
27102  EIF2AK1; eukaryotic translation initiation factor 2 alpha kinase 1
5610  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2
9451  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3
440275  EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4
4599  MX1; MX dynamin like GTPase 1
Perturbant
K22271  Core; Core protein
Reference
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
  Authors
Melen K, Fagerlund R, Nyqvist M, Keskinen P, Julkunen I
  Title
Expression of hepatitis C virus core protein inhibits interferon-induced nuclear import of STATs.
  Journal
J Med Virol 73:536-47 (2004)
DOI:10.1002/jmv.20123
Reference
  Authors
Lin W, Kim SS, Yeung E, Kamegaya Y, Blackard JT, Kim KA, Holtzman MJ, Chung RT
  Title
Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain.
  Journal
J Virol 80:9226-35 (2006)
DOI:10.1128/JVI.00459-06
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