KEGG   NETWORK: N00271Help
Entry
N00271                      Network                                

Name
HCV NS3/4A to RIG-I-like receptor signaling pathway
Definition
(hcvNS3,hcvNS4A) -| MAVS -> TRAF3 -> (TBK1+IKBKE) -> (IRF3,IRF7) => IFNB1
  Expanded
(K22273,K22274) -| 57506 -> 7187 -> (29110+9641) -> (3661,3665) => 3456
Class
nt06263 Hepatocellular carcinoma
nt06133 RIG-I signaling (viruses)
nt06163 Hepatitis C virus (HCV)
Type
Pathogen
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
57506  MAVS; mitochondrial antiviral signaling protein
7187  TRAF3; TNF receptor associated factor 3
29110  TBK1; TANK binding kinase 1
9641  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon
3661  IRF3; interferon regulatory factor 3
3665  IRF7; interferon regulatory factor 7
3456  IFNB1; interferon beta 1
Perturbant
K22273  NS3; serine protease NS3
K22274  NS4A; HCV non-structural protein 4A
Reference
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
  Authors
Horner SM, Gale M Jr
  Title
Regulation of hepatic innate immunity by hepatitis C virus.
  Journal
Nat Med 19:879-88 (2013)
DOI:10.1038/nm.3253
Reference
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
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