Entry |
|
Name |
HCV NS5A to oligoadenylate synthetase (OAS)/RNase L pathway
|
Definition |
NS5A -| OAS |
Expanded |
K22275 -| (4938,4939,4940) |
Class |
|
Type |
Pathogen
|
Pathway |
|
Disease |
H00048 | Hepatocellular carcinoma |
|
Gene |
4938 | OAS1; 2'-5'-oligoadenylate synthetase 1 |
4939 | OAS2; 2'-5'-oligoadenylate synthetase 2 |
4940 | OAS3; 2'-5'-oligoadenylate synthetase 3 |
|
Perturbant |
K22275 (NS5A) | NS5A; HCV non-structural protein 5A |
|
Reference |
|
Authors |
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H |
Title |
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner. |
Journal |
|
Reference |
|
Authors |
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O |
Title |
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies. |
Journal |
|
Reference |
|
Authors |
Horner SM, Gale M Jr |
Title |
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus. |
Journal |
|
LinkDB |
|