| Entry |
|
|---|
| Name |
HCV NS5A to oligoadenylate synthetase (OAS)/RNase L pathway
|
|---|
| Definition |
hcvNS5A -| OAS -> 2-5A -> RNASEL |
|---|
| Expanded |
K22275 -| (4938,4939,4940) -> C20935 -> 6041 |
|---|
| Class |
|
|---|
| Type |
Pathogen
|
|---|
| Pathway |
|
|---|
| Disease |
| H00048 | Hepatocellular carcinoma |
|
|---|
| Gene |
| 4938 | OAS1; 2'-5'-oligoadenylate synthetase 1 |
| 4939 | OAS2; 2'-5'-oligoadenylate synthetase 2 |
| 4940 | OAS3; 2'-5'-oligoadenylate synthetase 3 |
| 6041 | RNASEL; ribonuclease L |
|
|---|
| Perturbant |
| K22275 | NS5A; non-structural protein 5A |
|
|---|
| Reference |
|
|---|
| Authors |
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H |
|---|
| Title |
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O |
|---|
| Title |
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Horner SM, Gale M Jr |
|---|
| Title |
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus. |
|---|
| Journal |
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|---|
| LinkDB |
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