KEGG   NETWORK: N00288Help
Entry
N00288                      Network                                

Name
PTH-PTH1R-PKA signaling pathway
Definition
PTH -> PTH1R -> GNAS -> ADCY -> cAMP -> PKA
  Expanded
5741 -> 5745 -> 2778 -> (107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568)
Class
nt06318 CaSR-PTH signaling
Type
Reference
Pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04961  Endocrine and other factor-regulated calcium reabsorption
Gene
5741  PTH; parathyroid hormone
5745  PTH1R; parathyroid hormone 1 receptor
2778  GNAS; GNAS complex locus
107  ADCY1; adenylate cyclase 1
108  ADCY2; adenylate cyclase 2
109  ADCY3; adenylate cyclase 3
196883  ADCY4; adenylate cyclase 4
111  ADCY5; adenylate cyclase 5
112  ADCY6; adenylate cyclase 6
113  ADCY7; adenylate cyclase 7
114  ADCY8; adenylate cyclase 8
115  ADCY9; adenylate cyclase 9
5566  PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567  PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568  PRKACG; protein kinase cAMP-activated catalytic subunit gamma
Metabolite
C00575  3',5'-Cyclic AMP
Reference
  Authors
Bastepe M, Turan S, He Q
  Title
Heterotrimeric G proteins in the control of parathyroid hormone actions.
  Journal
J Mol Endocrinol 58:R203-R224 (2017)
DOI:10.1530/JME-16-0221
Reference
  Authors
Schipani E, Provot S
  Title
PTHrP, PTH, and the PTH/PTHrP receptor in endochondral bone development.
  Journal
Birth Defects Res C Embryo Today 69:352-62 (2003)
DOI:10.1002/bdrc.10028
Reference
  Authors
Jilka RL
  Title
Molecular and cellular mechanisms of the anabolic effect of intermittent PTH.
  Journal
Bone 40:1434-46 (2007)
DOI:10.1016/j.bone.2007.03.017
Reference
  Authors
Lee M, Partridge NC
  Title
Parathyroid hormone signaling in bone and kidney.
  Journal
Curr Opin Nephrol Hypertens 18:298-302 (2009)
DOI:10.1097/MNH.0b013e32832c2264
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