KEGG   NETWORK: N00290
Entry
N00290                      Network                                

Name
Mutation-inactivated MEN1 to transcription
Definition
(MEN1*+KMT2A) // (CDKN1B,CDKN2C)
  Expanded
(4221v1+4297) // (1027,1031)
Class
nt06360 Cushing syndrome
Type
Variant
Pathway
hsa04934  Cushing syndrome
Disease
H00247  Multiple endocrine neoplasia syndrome
H00246  Primary hyperparathyroidism
H01102  Pituitary adenomas
H01431  Cushing syndrome
H01522  Zollinger-Ellison syndrome
H00034  Carcinoid
H00033  Adrenal carcinoma
Gene
4221  MEN1; menin 1
4297  KMT2A; lysine methyltransferase 2A
1027  CDKN1B; cyclin dependent kinase inhibitor 1B
1031  CDKN2C; cyclin dependent kinase inhibitor 2C
Variant
4221v1 (MEN1*)  MEN1 mutation
Reference
  Authors
Lecoq AL, Kamenicky P, Guiochon-Mantel A, Chanson P
  Title
Genetic mutations in sporadic pituitary adenomas--what to screen for?
  Journal
Nat Rev Endocrinol 11:43-54 (2015)
DOI:10.1038/nrendo.2014.181
Reference
  Authors
Wu X, Hua X
  Title
Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.
  Journal
Curr Mol Med 8:805-15 (2008)
DOI:10.2174/156652408786733702
Reference
  Authors
Milne TA, Hughes CM, Lloyd R, Yang Z, Rozenblatt-Rosen O, Dou Y, Schnepp RW, Krankel C, Livolsi VA, Gibbs D, Hua X, Roeder RG, Meyerson M, Hess JL
  Title
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors.
  Journal
Proc Natl Acad Sci U S A 102:749-54 (2005)
DOI:10.1073/pnas.0408836102
Reference
  Authors
Tsukada T, Nagamura Y, Ohkura N
  Title
MEN1 gene and its mutations: basic and clinical implications.
  Journal
Cancer Sci 100:209-15 (2009)
DOI:10.1111/j.1349-7006.2008.01034.x
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