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Entry
N00301                      Network                                

Name
Angiotensin-aldosterone signaling pathway
Definition
Angiotensin -> AGTR1 -> GNAQ -> PLCB -> IP3 -> Ca2+ -> CALM -> CAMK -> CREB => CYP11B2 -> Aldosterone
  Expanded
C02135 -> 185 -> 2776 -> (23236,5330,5331,5332) -> C01245 -> C00076 -> (801,805,808) -> (8536,57118,57172,815,816,817,818,814) -> (10488,1385,1386,1388,148327,468,64764,84699,90993,9586) => 1585 -> C01780
Class
nt06316 Angiotensin-aldosterone signaling
Type
Reference
Pathway
hsa04925  Aldosterone synthesis and secretion
Gene
185  AGTR1; angiotensin II receptor type 1
2776  GNAQ; G protein subunit alpha q
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
801  CALM1; calmodulin 1
805  CALM2; calmodulin 2
808  CALM3; calmodulin 3
8536  CAMK1; calcium/calmodulin dependent protein kinase I
57118  CAMK1D; calcium/calmodulin dependent protein kinase ID
57172  CAMK1G; calcium/calmodulin dependent protein kinase IG
815  CAMK2A; calcium/calmodulin dependent protein kinase II alpha
816  CAMK2B; calcium/calmodulin dependent protein kinase II beta
817  CAMK2D; calcium/calmodulin dependent protein kinase II delta
818  CAMK2G; calcium/calmodulin dependent protein kinase II gamma
814  CAMK4; calcium/calmodulin dependent protein kinase IV
10488  CREB3; cAMP responsive element binding protein 3
1385  CREB1; cAMP responsive element binding protein 1
1386  ATF2; activating transcription factor 2
1388  ATF6B; activating transcription factor 6 beta
148327  CREB3L4; cAMP responsive element binding protein 3 like 4
468  ATF4; activating transcription factor 4
64764  CREB3L2; cAMP responsive element binding protein 3 like 2
84699  CREB3L3; cAMP responsive element binding protein 3 like 3
90993  CREB3L1; cAMP responsive element binding protein 3 like 1
9586  CREB5; cAMP responsive element binding protein 5
1585  CYP11B2; cytochrome P450 family 11 subfamily B member 2
Metabolite
C02135  Angiotensin II
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
C01780  Aldosterone
Reference
  Authors
Hattangady NG, Olala LO, Bollag WB, Rainey WE
  Title
Acute and chronic regulation of aldosterone production.
  Journal
Mol Cell Endocrinol 350:151-62 (2012)
DOI:10.1016/j.mce.2011.07.034
Reference
  Authors
Bollag WB
  Title
Regulation of aldosterone synthesis and secretion.
  Journal
Compr Physiol 4:1017-55 (2014)
DOI:10.1002/cphy.c130037
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