KEGG   NETWORK: N00325
Entry
N00325                      Network                                

Name
Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
Definition
RASD1* // GNAI // ADCY -> cAMP -> PKA -> CREB -> ACTH
  Expanded
51655v1 // (2770,2771,2773) // (107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568) -> (10488,1385,1386,1388,148327,468,64764,84699,90993,9586) -> 5443
Class
nt06310 CRH-ACTH-cortisol signaling
nt06360 Cushing syndrome
Type
Variant
Pathway
hsa04934  Cushing syndrome
Disease
H01431  Cushing syndrome
H01102  Pituitary adenomas
Gene
51655  RASD1; ras related dexamethasone induced 1
2770  GNAI1; G protein subunit alpha i1
2771  GNAI2; G protein subunit alpha i2
2773  GNAI3; G protein subunit alpha i3
107  ADCY1; adenylate cyclase 1
108  ADCY2; adenylate cyclase 2
109  ADCY3; adenylate cyclase 3
196883  ADCY4; adenylate cyclase 4
111  ADCY5; adenylate cyclase 5
112  ADCY6; adenylate cyclase 6
113  ADCY7; adenylate cyclase 7
114  ADCY8; adenylate cyclase 8
115  ADCY9; adenylate cyclase 9
5566  PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567  PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568  PRKACG; protein kinase cAMP-activated catalytic subunit gamma
10488  CREB3; cAMP responsive element binding protein 3
1385  CREB1; cAMP responsive element binding protein 1
1386  ATF2; activating transcription factor 2
1388  ATF6B; activating transcription factor 6 beta
148327  CREB3L4; cAMP responsive element binding protein 3 like 4
468  ATF4; activating transcription factor 4
64764  CREB3L2; cAMP responsive element binding protein 3 like 2
84699  CREB3L3; cAMP responsive element binding protein 3 like 3
90993  CREB3L1; cAMP responsive element binding protein 3 like 1
9586  CREB5; cAMP responsive element binding protein 5
5443  POMC; proopiomelanocortin
Variant
51655v1 (RASD1*)  RASD1 mutation
Metabolite
C00575  3',5'-Cyclic AMP
Reference
  Authors
Uzilov AV, Cheesman KC, Fink MY, Newman LC, Pandya C, Lalazar Y, Hefti M, Fowkes M, Deikus G, Lau CY, Moe AS, Kinoshita Y, Kasai Y, Zweig M, Gupta A, Starcevic D, Mahajan M, Schadt EE, Post KD, Donovan MJ, Sebra R, Chen R, Geer EB
  Title
Identification of a novel RASD1 somatic mutation in a USP8-mutated corticotroph adenoma.
  Journal
Cold Spring Harb Mol Case Stud 3:a001602 (2017)
DOI:10.1101/mcs.a001602
Reference
  Authors
Greenwood MP, Greenwood M, Mecawi AS, Antunes-Rodrigues J, Paton JF, Murphy D
  Title
Rasd1, a small G protein with a big role in the hypothalamic response to neuronal activation.
  Journal
Mol Brain 9:1 (2016)
DOI:10.1186/s13041-015-0182-2
Reference
  Authors
Blumer JB, Cismowski MJ, Sato M, Lanier SM
  Title
AGS proteins: receptor-independent activators of G-protein signaling.
  Journal
Trends Pharmacol Sci 26:470-6 (2005)
DOI:10.1016/j.tips.2005.07.003
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