KEGG   NETWORK: N00342
Entry
N00342                      Network                                

Name
MAGI-PTEN signaling pathway
Definition
MAGI -> PTEN -| PIP3 -> AKT
  Expanded
(9223,9863) -> 5728 -| C05981 -> (207,208,10000)
Class
nt06135 Cytoskeletal regulation (viruses)
nt06166 Human papillomavirus (HPV)
Type
Reference
Pathway
hsa04151  PI3K-Akt signaling pathway
Gene
9223  MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1
9863  MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2
5728  PTEN; phosphatase and tensin homolog
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
  Authors
Wu X, Hepner K, Castelino-Prabhu S, Do D, Kaye MB, Yuan XJ, Wood J, Ross C, Sawyers CL, Whang YE
  Title
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2.
  Journal
Proc Natl Acad Sci U S A 97:4233-8 (2000)
DOI:10.1073/pnas.97.8.4233
Reference
  Authors
Subauste MC, Nalbant P, Adamson ED, Hahn KM
  Title
Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2.
  Journal
J Biol Chem 280:5676-81 (2005)
DOI:10.1074/jbc.M405561200
Reference
  Authors
Tolkacheva T, Boddapati M, Sanfiz A, Tsuchida K, Kimmelman AC, Chan AM
  Title
Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at threonine 382 and 383.
  Journal
Cancer Res 61:4985-9 (2001)
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