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Entry
N00347                      Network                                

Name
p300-p21-Cell cycle G1/S
Definition
(ATM,ATR) -> TADA3 -> EP300 -> TP53 => CDKN1A -| (CCND+CDK4/6) -> RB1 // E2F
  Expanded
(472,545) -> 10474 -> 2033 -> 7157 => 1026 -| ((595,894,896)+(1019,1021)) -> 5925 // (1869,1870,1871)
Class
nt06130 Cell cycle (virus)
nt06166 Human papillomavirus (HPV)
Type
Reference
Pathway
hsa04110  Cell cycle
Gene
472  ATM; ATM serine/threonine kinase
545  ATR; ATR serine/threonine kinase
10474  TADA3; transcriptional adaptor 3
2033  EP300; E1A binding protein p300
7157  TP53; tumor protein p53
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
595  CCND1; cyclin D1
894  CCND2; cyclin D2
896  CCND3; cyclin D3
1019  CDK4; cyclin dependent kinase 4
1021  CDK6; cyclin dependent kinase 6
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Reference
  Authors
Vuong L, Conley SM, Al-Ubaidi MR
  Title
Expression and role of p53 in the retina.
  Journal
Invest Ophthalmol Vis Sci 53:1362-71 (2012)
DOI:10.1167/iovs.11-8909
Reference
  Authors
Chand V, Nandi D, Mangla AG, Sharma P, Nag A
  Title
Tale of a multifaceted co-activator, hADA3: from embryogenesis to cancer and beyond.
  Journal
Open Biol 6:160153 (2016)
DOI:10.1098/rsob.160153
Reference
  Authors
Nag A, Germaniuk-Kurowska A, Dimri M, Sassack MA, Gurumurthy CB, Gao Q, Dimri G, Band H, Band V
  Title
An essential role of human Ada3 in p53 acetylation.
  Journal
J Biol Chem 282:8812-20 (2007)
DOI:10.1074/jbc.M610443200
Reference
  Authors
Wong PP, Pickard A, McCance DJ
  Title
p300 alters keratinocyte cell growth and differentiation through regulation of p21(Waf1/CIP1).
  Journal
PLoS One 5:e8369 (2010)
DOI:10.1371/journal.pone.0008369
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